Which layer of skin is primarily responsible for sensation?

The dermis is primarily responsible for sensation because it contains a rich network of nerve endings and sensory receptors. This layer of skin lies beneath the epidermis and is composed of connective tissue, which houses various structures such as blood vessels, hair follicles, and glands.

Within the dermis, there are specialized nerve receptors that respond to different stimuli such as touch, pressure, pain, and temperature. These receptors send signals to the brain, allowing us to perceive sensations.

In contrast, the epidermis, while essential for providing a protective barrier and containing some nerve endings, does not have the same density or variety of sensory receptors as the dermis. The hypodermis, also known as subcutaneous tissue, primarily serves as a layer of insulation and cushioning, rather than sensation. The stratum lucidum, which is a thin, clear layer found in thick skin areas, mainly provides additional protection and does not play a significant role in sensory perception. Thus, the dermis is the correct answer for its vital contribution to our sense of touch and sensation.